First total synthesis and structural confirmation of fluvirucinine A2 via an iterative ring expansion strategy.
نویسندگان
چکیده
The first asymmetric total synthesis of fluvirucinine A(2) has been accomplished. A key feature of the synthesis is an iterative lactam ring expansion to provide rapid access to the 14-membered lactam skeleton and three stereogenic centers. The excellent remote control of the three stereogenic centers relied on stereoselective amidoalkylation followed by an amide-enolate-induced aza-Claisen rearrangement. In addition, the structure of fluvirucinine A(2) has been completely elucidated by our total synthesis.
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ورودعنوان ژورنال:
- Organic letters
دوره 12 9 شماره
صفحات -
تاریخ انتشار 2010